Journal article
Antibodies mediate formation of neutrophil extracellular traps in the middle ear and facilitate secondary pneumococcal otitis media
KR Short, M von Köckritz-Blickwede, JD Langereis, KY Chew, ER Job, CW Armitage, B Hatcher, K Fujihashi, PC Reading, PW Hermans, OL Wijburg, DA Diavatopoulos
Infection and Immunity | Published : 2014
DOI: 10.1128/IAI.01104-13
Abstract
Otitis media (OM) (a middle ear infection) is a common childhood illness that can leave some children with permanent hearing loss.OMcan arise following infection with a variety of different pathogens, including a coinfection with influenza A virus (IAV) and Streptococcus pneumoniae (the pneumococcus). We and others have demonstrated that coinfection with IAV facilitates the replication of pneumococci in the middle ear. Specifically, we used a mouse model of OM to show that IAV facilitates the outgrowth of S. pneumoniae in the middle ear by inducing middle ear inflammation. Here, we seek to understand how the host inflammatory response facilitates bacterial outgrowth in the middle ear. Using ..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
K. R. S. was supported in part by a GlaxoSmithKline postgraduate support grant, an Elizabeth and Vernon Puzey postgraduate research scholarship, and an NHMRC CJ Martin postdoctoral fellowship (1054081). D. A. D. is supported by the 7th Framework Programme of the European Commission (ETB grant 08010). O.L.W. is supported by a Career Development Fellowship (R. D. Wright Fellowships) from the Australian National Health and Medical Research Council. The Melbourne World Health Organization Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health and Ageing. Part of this work was supported by Australia National Health and Medical Research Council (NHMRC) grant number 1044976.